Description
An inverse agonist of RORγ (IC50 = 17 nM in a transactivation assay); selective for RORγ over RORα; inhibits IL-17A and IL-22 protein secretion from isolated human peripheral blood T cells grown under Th17 skewing conditions (IC50 = 3.2 nM); topical application (1% ointment) reduces dermal symptoms in a mouse model of imiquimod-induced psoriasis